COVID-19 and Infectious Disease Resources

Critical Tools for Coronavirus (COVID-19) Research

Supporting scientists with up-to-date resources for COVID-19 and infectious disease research

Explore a selection of publications and preprints that showcase the latest research on COVID-19.

Aguiar et al., 2020 Biorxiv
Brann et al., 2020 Biorxiv

Surveyed the expression of ACE2 in colon tissue from healthy adults and colorectal cancer patients via single cell RNA-sequencing, revealing predominant expression in colon epithelial cells and a gradual increase of expression from healthy controls, to adenoma, to colorectal cancer patients.
Duan et al., 2020 Biorxiv
Fodoulian et al., 2020 Biorxiv
Goplen et al., 2020 Biorxiv
Guo et al., 2020 Biorxiv
Han et al., 2020 Biorxiv

He et al., 2020 Biorxiv
Single-cell transcriptome profiling an adult human cell atlas of 15 major organs
Performed a comprehensive single cell transcriptional analysis of 88,622 cells derived from 15 tissue organs of one adult donor, evaluating ACE2 expression across the 15 autopsied tissues and generating an adult human cell atlas (AHCA).

Huang et al., 2020 Medrxiv
Lee et al., 2020 Biorxiv

Li et al., 2020 PLOS one
The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study
Evaluated maternal-fetal interface and fetal organ single cell RNA-sequencing datasets to determine cell specific expression of ACE2, observing extensive expression of ACE2 in cells of the decidua and placenta, and, in neonatal mice, high expression in the lung, suggesting the capacity for vertical transmission of SARS-CoV-2 to the fetus.

Patterson et al., 2020 Medrxiv
Ravindra et al., 2020 Biorxiv

Wang et al., 2020 Medrxiv
ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism
Performed single cell RNA-sequencing on intestine samples from control subjects and patients with colitis or inflammatory bowel
Wang et al., 2020 Biorxiv
Wang and Xu, 2020 [preprint]
scRNA-seq Profiling of Human Testes Reveals the Presence of ACE2 Receptor, a Target for SARS-CoV-2 Infection, in Spermatogonia, Leydig and Sertoli Cells
Leveraged an existing single cell RNA-sequencing dataset to investigate the expression pattern of ACE2 in adult human testis, finding enriched expression in spermatogonia, Leydig and Sertoli cells, suggesting human testes are a potential target of SARS-CoV-2 infection.

Wei et al., 2020 SSRN
Viral Invasion and Type I Interferon Response Characterize the Immunophenotypes during COVID-19 Infection
Profiled the immunophenotypes of PBMCs from four patients before, during, and after ICU using single cell RNA-sequencing, revealing gene expression signatures of viral invasion and type I interferon responses for severe manifestation of SARS-CoV-2 infection.
Xu et al., 2020 International Journal of Oral Science
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa
Analyzed a single cell RNA-sequencing dataset of the mucosa of the oral cavity, observing heightened expression of ACE2 in epithelial cells of the tongue and suggesting the oral cavity is potentially high risk for infectious susceptibility to SARS-CoV-2.
Zhao et al., 2020 Biorxiv
Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids
Infected human liver ductal organoids with SARS-CoV-2, leveraging single cell RNA-sequencing to determine that long-term liver ductal organoid culture preserved the human specific ACE2+ population of cholangiocytes and supported robust viral replication, leading to impaired tight junction formation and bile acid transportation.
Zhao et al., 2020 Biorxiv
Analyzed the expression profile of ACE2 in normal human lungs using a public single cell RNA-sequencing dataset, showing the viral receptor is concentrated in a small population of type II alveolar cells that upregulate other genes associated with viral reproduction and transmission.
Zhou et al., 2020 Biorxiv
Ziegler et al., 2020 [Cell Press preprint]
Leveraged human and non-human primate single cell RNA-sequencing datasets to discover that SARS-CoV-2 may exploit IFN-driven upregulation of ACE2 to enhance infection and identify vulnerable cell populations co-expressing ACE2 and TMPRSS2.

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