Single cell sequencing technologies can be used to profile tissues and identify the molecular drivers of disease, study immune function, identify developmental trajectories, and decipher the tumor microenvironment. In this recent publication from Azizi et al., researchers at Memorial Sloan Kettering Cancer Center (New York, NY, USA) performed large-scale, single cell analysis of immune cells within the breast tumor microenvironment. They developed computational tools to normalize and cluster single cell RNA sequencing data across multiple tumors, revealing a continuum of activation and differentiation states for tumor-associated T cells and macrophages.
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