Application Note

Exploring AD-like pathology at
subcellular resolution using Xenium In Situ

Alzheimer’s disease, the most common type of dementia, is famously characterized by the heavy accumulation of amyloid plaques in the brain: but how can researchers determine the impact of these plaques on the cellular microenvironment?

In a new application note, we dug deep into this question using our Xenium In Situ technology to conduct a large-scale analysis in a mouse model of Alzheimer's disease. Sign up to download your copy and discover how this cutting-edge technology:

• Permitted the analysis of hundreds of transcripts at subcellular resolution in individual cells surrounding amyloid plaques
• Allowed the overlay of plaque-induced gene expression, amyloid plaque localization, and morphology all on the same section
• Enabled the analysis of cell type composition in health and disease, as well as characterizing disease-associated microglia and astrocytes surrounding plaques.