Research Snapshot

How single cell immune profiling
solved renal cancer mysteries

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Clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer, is a story of contradictions. Its very low tumor mutational burden does not lead to checkpoint inhibitor responses, and its highly immune-infiltrated tumors still produce poor outcomes. So, when researchers at the Francis Crick Institute tested the efficacy of nivolumab, a new drug candidate, they turned to Chromium Single Cell Immune Profiling.

In our new Research Snapshot, you'll find out how the researchers:

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  • Discovered differences in nivolumab responders vs non-responders
  • Identified clonotypes based on TCR sequences
  • Validated findings against 100,000 T cells

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