Research Program

Visium Clinical Translational Research Network

Transform clinical translational research with spatial gene expression

 
ENHANCE clinical translational research workflows with Visium spatial solutions
ACCELERATE biomarker discovery and therapeutic pipelines
ENABLE interdisciplinary clinical translational research
FOSTER a network of researchers bridging the gap between bench and bedside
The relationship between cells and their relative locations within a tissue sample can be critical to understanding mechanisms of human disease, developing therapeutic interventions, and evaluating the basis of therapeutic response in clinical trials. The Visium Spatial Gene Expression Solution allows researchers to measure total gene activity in a fresh-frozen tissue section and map where that activity is occurring in the morphological context of the tissue, which overcomes the limitations of traditional tools that rely on a few validated antibodies. With an efficient and intuitive workflow, Visium Spatial Solutions can aid numerous clinical translational research applications, including:
  • Biomarker discovery: identify gene signatures associated with disease progression or drug response/resistance, and the cells that express them.
  • Engineered immune cell therapy: evaluate target antigen expression and monitor immune cell infiltration, activation, and efficacy in solid tumors.
  • CDx and clinical trial development: improve stratification for companion diagnostics and clinical trials.

Goals of the CTRN:

ENHANCE clinical translational research workflows with Visium spatial solutions

ACCELERATE biomarker discovery and therapeutic pipelines

ENABLE interdisciplinary clinical translational research

FOSTER a network of researchers bridging the gap between bench and bedside

The relationship between cells and their relative locations within a tissue sample can be critical to understanding mechanisms of human disease, developing therapeutic interventions, and evaluating the basis of therapeutic response in clinical trials. The Visium Spatial Gene Expression Solution allows researchers to measure total gene activity in a fresh-frozen tissue section and map where that activity is occurring in the morphological context of the tissue, which overcomes the limitations of traditional tools that rely on a few validated antibodies. With an efficient and intuitive workflow, Visium Spatial Solutions can aid numerous clinical translational research applications, including:
  • Biomarker discovery: identify gene signatures associated with disease progression or drug response/resistance, and the cells that express them.
  • Engineered immune cell therapy: evaluate target antigen expression and monitor immune cell infiltration, activation, and efficacy in solid tumors.
  • CDx and clinical trial development: improve stratification for companion diagnostics and clinical trials.


Members

The first 45 members of 10x Genomics’ Visium CTRN represent a diverse range of studies that are taking place around the globe. The CTRN will connect researchers at 39 different institutions, including:

Institution
Name  
Duke_university_logo.png Simon Gregory
Duke University
Johns_hopkins_logo.png Elana Fertig, Elizabeth Jaffee, Luciane Kagohara
Johns Hopkins Medical Institutions
Univ_of_Michigan_logo.png Evan Keller
University of Michigan Rogel Cancer Center
Univ_Miami_Bascom_eye_inst_logo.png
Michael Durante, William Harbour
Sylvester Comprehensive Cancer Center and Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Massachusetts_General_hospital_logo.png Sophia Shalhout (David Miller lab)
Mass General Cancer Center
Lieber_institute_logo.png Andrew Jaffe, Keri Martinowich, Kristen Maynard
Lieber Institute for Brian Development
GSK_logo.png
Jan Roger, Crysthiane Ishiy
GSK
Barcelona_supercomputing_center_logo.png Joseph carreraa Leukaemia Logo.png Eduard Porta
Barcelona Supercomputing Center, Josep Carreras Leukaemia Research Institute
Centre_de_Recherche_des_Cordeliers_logo.png
Wolf H. Fridman, Catherine Fridman, Maxime Meylan
Centre de Recherche des Cordeliers (Inserm, Sorbonne Université, Université de Paris)
Centre_Recherche_in_Cancerologie_Lyon_logo.png Phillippe Bertolino, Gerald Raverot
Cancer Research Centre of Lyon 
Garvan_institutute_logo.png Alex Swarbrick
Garvan Institute of Medical Research
Nanjing_Univ_medical_logo.png Shiping Jiao
Nanjing Drum Tower Hospital
A-star_singapore_logo.png Bo Li (Shyam Prabhakar lab)
A*Star - Genome Institute of Singapore
A-star_singapore_logo.png Ankur Sharma
A*Star - Genome Institute of Singapore
A-star_singapore_logo.png
Joe Yeong
A*Star - Institute of Molecular & Cell Biology (IMCB)
Hospital_italiano_buenos_aires_logo.png Hernan Garcia Rivello
Hospital Italiano Buenos Aires, IMTIB
LMU_Klinikum_logo.png Sebastian Theurich
Ludwig-Maximilians University Munich
Humanitas_Research_Hospital_logo.png Leonardo Elia
Humanitas Research Hospital
imagine_logo.png Mickael Menager
Institut Imagine
Queensland_university_Tech_logo.png Arutha Kulasinghe
Queensland University of Technology
Riken_logo.png Tomohiro Miyai
RIKEN Center for Integrative Medical Sciences
Riken_logo.png Minoru Takasato
RIKEN Center for Biosystems Dynamics Research
BRFAA_hor_big.jpg
Emmanouil Athanasiadis
Biomedical Research Foundation Academy of Athens