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Transform clinical translational research with spatial gene expression

 
ENHANCE clinical translational research workflows with Visium spatial solutions
ACCELERATE biomarker discovery and therapeutic pipelines
ENABLE interdisciplinary clinical translational research
FOSTER a network of researchers bridging the gap between bench and bedside
The relationship between cells and their relative locations within a tissue sample can be critical to understanding mechanisms of human disease, developing therapeutic interventions, and evaluating the basis of therapeutic response in clinical trials. The Visium Spatial Gene Expression Solution allows researchers to measure total gene activity in a fresh-frozen tissue section and map where that activity is occurring in the morphological context of the tissue, which overcomes the limitations of traditional tools that rely on a few validated antibodies. With an efficient and intuitive workflow, Visium Spatial Solutions can aid numerous clinical translational research applications, including:
  • Biomarker discovery: identify gene signatures associated with disease progression or drug response/resistance, and the cells that express them.
  • Engineered immune cell therapy: evaluate target antigen expression and monitor immune cell infiltration, activation, and efficacy in solid tumors.
  • CDx and clinical trial development: improve stratification for companion diagnostics and clinical trials.

Goals of the CTRN:

ENHANCE clinical translational research workflows with Visium spatial solutions

ACCELERATE biomarker discovery and therapeutic pipelines

ENABLE interdisciplinary clinical translational research

FOSTER a network of researchers bridging the gap between bench and bedside

The relationship between cells and their relative locations within a tissue sample can be critical to understanding mechanisms of human disease, developing therapeutic interventions, and evaluating the basis of therapeutic response in clinical trials. The Visium Spatial Gene Expression Solution allows researchers to measure total gene activity in a fresh-frozen tissue section and map where that activity is occurring in the morphological context of the tissue, which overcomes the limitations of traditional tools that rely on a few validated antibodies. With an efficient and intuitive workflow, Visium Spatial Solutions can aid numerous clinical translational research applications, including:
  • Biomarker discovery: identify gene signatures associated with disease progression or drug response/resistance, and the cells that express them.
  • Engineered immune cell therapy: evaluate target antigen expression and monitor immune cell infiltration, activation, and efficacy in solid tumors.
  • CDx and clinical trial development: improve stratification for companion diagnostics and clinical trials.


Members

Newest Members

The 10x Genomics’ CTRN represents a diverse range of translational studies that are taking place around the globe. Welcome to our newest members.

Institution Name
Baylor College of Medicine
Ivan Rosas
Enrico Barrozo
Kjersti Aagaard
Brigham and Women's Hospital Scott Rodig
Centre Léon Bérard
Pierre Saintigny
St. Anna Kinderkrebsforschung Children's Cancer Research Institute Eleni Tomazou
City of Hope National Medical Center Christina Wei
Duke NUS Medical School Huimei Chen
Erasmus University Medical Center
Riccardo Fodde
Fred Hutchinson Cancer Research Center
Susan Bullman
IRCCS Fondazione Policlinico Universitario Agostino Gemelli Carmine Carbone
Harry Perkins Institute of Medical Research
Alistair Forrest
Huaqiao University Rongqin Ke
Indiana University School of Medicine
Sunil Badve
Institut Gustave Roussy Antonin Marchais
Ludwig-Maximilians University Munich Viktoria Ruf
Max Delbrück Center for Molecular Medicine Berlin Nikolaus Rajewsky
McGill University
Corina Nagy
MD Anderson Cancer Center
Anirban Maitra
National Chiao Tung University, Academia Sinica
Tai-Ming Ko
Novo Nordisk Peter Kvist
Peking University, Beijing Cancer Hospital Leon Xiangyu Gao
Peter MacCallum Cancer Centre
Stephen Fox
Samsung Genome Institute
Woong-Yang Park
Shenzhen Bay Laboratory
Joe Zhang
St. Jude Children's Research Hospital Jiyang Yu
Tomsk National Research Medical Center of the Russian Academy of Sciences
Evgeny Denisov
University College London
Theodoros Xenakis
University of Queensland, Institute for Molecular Bioscience Quan Nguyen
University of Texas Southwestern Medical Center Yujin Hoshida
University of Tokyo Yutaka Suzuki

Current Members
The first 45 members of 10x Genomics’ Visium CTRN represent a diverse range of studies that are taking place around the globe. The CTRN will connect researchers at 39 different institutions, including:

Institution
Name  
A*Star - GIS Bo Li (Shyam Prabhakar lab)
A*Star - Institute of Molecular & Cell Biology (IMCB) Joe Yeong
Barcelona Supercomputing Center
Josep Carreras Leukaemia Research Institute
Eduard Porta
Biomedical Research Foundation of the Academy of Athens Emmanouil Athanasiadis
Brigham and Women's Hospital, Broad Institute Nikolaos Patsopoulos
Cancer Research Center of Lyon
Philippe Bertolino
Gerald Raverot
Cancer Research UK Cambridge Institute Martin Miller
Cedars Sinai Medical Center Jasmine Plummer
Stephanie Chen
Centre de Recherche des Cordeliers
Wolf H. Fridman
Catherine Fridman
Maxime Meylan
Columbia University Claudia Doege
Gulam Manji
Duke University Simon Gregory
Garvan Institute of Medical Research Alex Swarbrick
Joseph Powell
GlaxoSmithKline
Crysthiane Ishiy
Jan Roger
Harry Perkins Institute of Medical Research Ankur Sharma
Hospital Italiano Buenos Aires - IMTIB Hernan Garcia Rivello
Humanitas Research Hospital Leonardo Elia
Institut Imagine Mickael Menager
Lieber Institute for Brain Development
Andrew Jaffe
Keri Martinowich
Kristen Maynard
Johns Hopkins Medical Institutions
Elana Fertig
Luciane Kagohara
Elizabeth Jaffee
Keio University
Kenta Masuda
Jun Kohyama
KU Leuven Gianluca Matteoli
Ludwig-Maximilians University Munich Sebastian Theurich
Mass General Cancer Center, MGH Sophia Shalhout
Memorial Sloan Kettering Cancer Center Ignacio Vazquez-Garcia
Nanjing Durm Tower Hospital Shiping Jiao
National Cancer Centre Singapore Chit Lai Chee
Oxford University Zhiyuan Hu
Peking University Sen Gao
Queensland University of Technology Arutha Kulasinghe
RIKEN Center for Integrative Medical Sciences Tomohiro Miyai
Riken Human Organogenesis Minoru Takasato
St. Jude Children's Research Hospital Anand Patel
Xiang Chen
Stanford University Magdalena Matusiak
Sunnybrook Research Institute
Kabir Khan
Sylvester Comprehensive Cancer Center and Bascom Palmer Eye Institute
University of Miami Health System
Michael Durante
J. William Harbour
UCL GOS Institute of Child Health
Jessica Pickles
University of Edinburgh
Prakash Ramachandran
Ross Dobie
University of Michigan Rogel Cancer Center
Evan Keller
Washington University in St. Louis Allegra Petti

 

Publications from CTRN members using Visium


 

Learn how CTRN members are applying spatial biology in translational research

Oncology

 
An integrated single cell and spatial atlas of localised breast cancer
Alex Swarbrick, PhD
Associate Professor, UNSW Sydney
Garvan Institute of Medical Research
 
Exploring breast tumour immunology through integrated single-cell and spatial multiomics
Alex Swarbrick, PhD
Associate Professor, UNSW Sydney
Garvan Institute of Medical Research
 
Genetic and spatial heterogeneity in human papilloma virus associated cancer of the oropharynx
Joseph Powell, PhD
Associate Professor
Garvan Institute of Medical Research

Neuroscience

 
Spatial resolution of the developing human cortex
Jasmine Plummer PhD
Associate Director, Applied Genomics, Computational & Translational (AGCT) Core
Cedars Sinai Medical Center
 
Transcriptome-Scale Spatial Gene Expression in the Human Dorsolaterial Prefrontal Cortex
Kristen Maynard, PhD
Spatial Solutions
Lieber Institute for Brain Development

CTRN Member Panel Discussion

 
Hear CTRN members discuss the impact of spatial biology in translational research
Featuring:
Mickael Menager, Head of the ATIP-Avenir team and & Lab Tech Single-Cell, Imagine Institute
Prakash Ramachandran, MRC Clinican Scientist, University of Edinburgh
Philippe Bertolino, Head of Tumour Environment & Pituitary Oncology, Inserm - Cancer Research Center Lyon

CTRN members on the impact of Visium in translational research

  Discover the exciting future that researchers like Elizabeth Jaffee, MD, and Elana Fertig, PhD, are envisioning with the power of spatially resolved transcriptomics for FFPE samples.