Goals of the CTRN:
ENHANCE clinical translational research workflows with Visium spatial solutions
ACCELERATE biomarker discovery and therapeutic pipelines
ENABLE interdisciplinary clinical translational research
FOSTER a network of researchers bridging the gap between bench and bedside
The relationship between cells and their relative locations within a tissue sample can be critical to understanding mechanisms of human disease, developing therapeutic interventions, and evaluating the basis of therapeutic response in clinical trials. The Visium Spatial Gene Expression Solution allows researchers to measure total gene activity in a fresh-frozen tissue section and map where that activity is occurring in the morphological context of the tissue, which overcomes the limitations of traditional tools that rely on a few validated antibodies. With an efficient and intuitive workflow, Visium Spatial Solutions can aid numerous clinical translational research applications, including:
- Biomarker discovery: identify gene signatures associated with disease progression or drug response/resistance, and the cells that express them.
- Engineered immune cell therapy: evaluate target antigen expression and monitor immune cell infiltration, activation, and efficacy in solid tumors.
- CDx and clinical trial development: improve stratification for companion diagnostics and clinical trials.
Members
Newest Members
The 10x Genomics’ CTRN represents a diverse range of translational studies that are taking place around the globe. Welcome to our newest members.
| Institution |
Name |
| Baylor College of Medicine |
Ivan Rosas
Enrico Barrozo
Kjersti Aagaard
|
| Brigham and Women's Hospital |
Scott Rodig |
Centre Léon Bérard
|
Pierre Saintigny |
| St. Anna Kinderkrebsforschung Children's Cancer Research Institute |
Eleni Tomazou
|
| City of Hope National Medical Center |
Christina Wei
|
| Duke NUS Medical School |
Huimei Chen |
Erasmus University Medical Center
|
Riccardo Fodde
|
Fred Hutchinson Cancer Research Center
|
Susan Bullman
|
| IRCCS Fondazione Policlinico Universitario Agostino Gemelli |
Carmine Carbone
|
Harry Perkins Institute of Medical Research
|
Alistair Forrest
|
| Huaqiao University |
Rongqin Ke |
Indiana University School of Medicine
|
Sunil Badve
|
| Institut Gustave Roussy |
Antonin Marchais
|
| Ludwig-Maximilians University Munich |
Viktoria Ruf
|
| Max Delbrück Center for Molecular Medicine Berlin |
Nikolaus Rajewsky
|
McGill University
|
Corina Nagy
|
MD Anderson Cancer Center
|
Anirban Maitra
|
National Chiao Tung University, Academia Sinica
|
Tai-Ming Ko
|
| Novo Nordisk |
Peter Kvist |
| Peking University, Beijing Cancer Hospital |
Leon Xiangyu Gao
|
Peter MacCallum Cancer Centre
|
Stephen Fox
|
Samsung Genome Institute
|
Woong-Yang Park
|
Shenzhen Bay Laboratory
|
Joe Zhang
|
| St. Jude Children's Research Hospital |
Jiyang Yu
|
Tomsk National Research Medical Center of the Russian Academy of Sciences
|
Evgeny Denisov
|
University College London
|
Theodoros Xenakis
|
| University of Queensland, Institute for Molecular Bioscience |
Quan Nguyen
|
| University of Texas Southwestern Medical Center |
Yujin Hoshida
|
| University of Tokyo |
Yutaka Suzuki |
Current Members
The first 45 members of 10x Genomics’ Visium CTRN represent a diverse range of studies that are taking place around the globe. The CTRN will connect researchers at 39 different institutions, including:
Institution
|
Name |
| A*Star - GIS |
Bo Li (Shyam Prabhakar lab) |
| A*Star - Institute of Molecular & Cell Biology (IMCB) |
Joe Yeong |
|
Barcelona Supercomputing Center
Josep Carreras Leukaemia Research Institute
|
Eduard Porta |
| Biomedical Research Foundation of the Academy of Athens |
Emmanouil Athanasiadis |
| Brigham and Women's Hospital, Broad Institute |
Nikolaos Patsopoulos |
| Cancer Research Center of Lyon |
Philippe Bertolino
Gerald Raverot
|
| Cancer Research UK Cambridge Institute |
Martin Miller |
| Cedars Sinai Medical Center |
Jasmine Plummer
Stephanie Chen |
|
Centre de Recherche des Cordeliers
|
Wolf H. Fridman
Catherine Fridman
Maxime Meylan
|
| Columbia University |
Claudia Doege
Gulam Manji |
| Duke University |
Simon Gregory |
| Garvan Institute of Medical Research |
Alex Swarbrick
Joseph Powell |
| GlaxoSmithKline |
Crysthiane Ishiy
Jan Roger
|
| Harry Perkins Institute of Medical Research |
Ankur Sharma |
| Hospital Italiano Buenos Aires - IMTIB |
Hernan Garcia Rivello
|
| Humanitas Research Hospital |
Leonardo Elia
|
| Institut Imagine |
Mickael Menager
|
| Lieber Institute for Brain Development |
Andrew Jaffe
Keri Martinowich
Kristen Maynard
|
| Johns Hopkins Medical Institutions |
Elana Fertig
Luciane Kagohara
Elizabeth Jaffee
|
| Keio University |
Kenta Masuda
Jun Kohyama
|
| KU Leuven |
Gianluca Matteoli |
| Ludwig-Maximilians University Munich |
Sebastian Theurich
|
| Mass General Cancer Center, MGH |
Sophia Shalhout
|
| Memorial Sloan Kettering Cancer Center |
Ignacio Vazquez-Garcia
|
| Nanjing Durm Tower Hospital |
Shiping Jiao
|
| National Cancer Centre Singapore |
Chit Lai Chee
|
| Oxford University |
Zhiyuan Hu
|
| Peking University |
Sen Gao
|
| Queensland University of Technology |
Arutha Kulasinghe
|
| RIKEN Center for Integrative Medical Sciences |
Tomohiro Miyai
|
| Riken Human Organogenesis |
Minoru Takasato |
| St. Jude Children's Research Hospital |
Anand Patel
Xiang Chen |
| Stanford University |
Magdalena Matusiak
|
Sunnybrook Research Institute
|
Kabir Khan
|
|
Sylvester Comprehensive Cancer Center and Bascom Palmer Eye Institute
University of Miami Health System
|
Michael Durante
J. William Harbour
|
UCL GOS Institute of Child Health
|
Jessica Pickles
|
University of Edinburgh
|
Prakash Ramachandran
Ross Dobie |
University of Michigan Rogel Cancer Center
|
Evan Keller
|
| Washington University in St. Louis |
Allegra Petti |
Publications from CTRN members using Visium
Learn how CTRN members are applying spatial biology in translational research
Oncology
|
|
An integrated single cell and spatial atlas of localised breast cancer
Alex Swarbrick, PhD
Associate Professor, UNSW Sydney
Garvan Institute of Medical Research
|
|
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Exploring breast tumour immunology through integrated single-cell and spatial multiomics
Alex Swarbrick, PhD
Associate Professor, UNSW Sydney
Garvan Institute of Medical Research
|
|
|
Genetic and spatial heterogeneity in human papilloma virus associated cancer of the oropharynx
Joseph Powell, PhD
Associate Professor
Garvan Institute of Medical Research
|
Neuroscience
|
|
Spatial resolution of the developing human cortex
Jasmine Plummer PhD
Associate Director, Applied Genomics, Computational & Translational (AGCT) Core
Cedars Sinai Medical Center
|
|
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Transcriptome-Scale Spatial Gene Expression in the Human Dorsolaterial Prefrontal Cortex
Kristen Maynard, PhD
Spatial Solutions
Lieber Institute for Brain Development
|
CTRN Member Panel Discussion
|
|
Hear CTRN members discuss the impact of spatial biology in translational research
Featuring:
Mickael Menager, Head of the ATIP-Avenir team and & Lab Tech Single-Cell, Imagine Institute
Prakash Ramachandran, MRC Clinican Scientist, University of Edinburgh
Philippe Bertolino, Head of Tumour Environment & Pituitary Oncology, Inserm - Cancer Research Center Lyon
|
CTRN members on the impact of Visium in translational research
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Discover the exciting future that researchers like Elizabeth Jaffee, MD, and Elana Fertig, PhD, are envisioning with the power of spatially resolved transcriptomics for FFPE samples. |
