Full-width Headline

Full Width Form + Headline

The 10x Genomics Chromium Single Cell CNV Solution has proven effective for identification of multi-megabase copy number variants across hundreds to thousands of single cells. However, current methods focus on measuring differences in total copy number at genomic loci, ignoring allele-specific copy number changes. As a result, Dr. Ben Raphael and colleagues developed CHISEL, the first algorithm to infer allele- and haplotype-specific copy numbers in individual cells and subpopulations of cells.


Join Dr. Raphael for a live webinar to learn more about how CHISEL provides a powerful tool to realize the potential of low-coverage whole genome single cell sequencing data for studies of tumor heterogeneity and evolution.

During this webinar you will learn about:

  • The application of CHISEL to single-cell sequencing using two breast cancer datasets to identify extensive allele-specific copy number aberrations (CNAs) including copy-neutral loss of heterozygosity (LOH), whole-genome duplications (WGDs), and mirrored subclonal CNAs.

  • The identification of allele-specific CNAs that affect several well-known breast cancer genes, but were invisible to total copy number analysis.

  • The ability of CHISEL’s allele- and haplotype-specific copy numbers to yield a more refined reconstruction of tumor evolution including: low-frequency clones distinguished by unique CNAs, the timing of allele-specific CNAs before and after WGDs, and evidence of convergent evolution.


Speaker:

Dr. Ben Raphael
Professor of Computer Science, Princeton University

Ben Raphael is a Professor of Computer Science at Princeton University. His research focuses on the design and application of novel algorithms for the interpretation of biological data. Recent areas of emphasis include cancer evolution, network/pathway analysis of genetic variants, and structural variation in human and cancer genomes. His group’s algorithms have been used in multiple projects from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC). He is the recipient of the Alfred P. Sloan Research Fellowship, the NSF CAREER award, and a Career Award at the Scientific Interface from the Burroughs Wellcome Fund.



Can't make it live? No problem, register here and we'll send you an email when the recording is available.
ALT TEXT

Speakers

ALT TEXT

Lorem ipsum, dolor sit amet consectetur adipisicing elit.

ALT TEXT

Lorem ipsum, dolor sit amet consectetur adipisicing elit.

ALT TEXT

Lorem ipsum, dolor sit amet consectetur adipisicing elit.

Register Now
October 15, 2019
9:00 am PST
ALT TEXT
Click here

ALT TEXT
ALT TEXT

ALT TEXT

Title

ALT TEXT

ALT TEXT

ALT TEXT

ALT TEXT