Chromium Xo: A low-cost instrument for high-performance single cell
Ever feel like you’re being asked to do more research with less funding? Chromium Xo makes it possible.
Bring the advantage of high reproducibility and time savings from automated, instrument-supported single cell partitioning to your 3’ gene expression studies for a significantly lower cost.
And to help you make the most out of the incredible data you will get, you'll have access to Automated Cell Annotation1 for faster and easier analysis, included in our complimentary software.
As we work to make single cell more accessible at lower costs, Chromium Xo is just one of many Chromium innovations that provide exceptional performance and reduce budget constraints at every step.
Higher performance for trusted results and incredible savings

- See how up to 80% cell capture rates and higher gene sensitivity provides high-quality results for low-expressed transcripts and fragile cells
- Generate more usable reads and detect more genes at lower read depths, saving up to 50% on sequencing costs
- Run cost-effective studies—even at smaller scales or with limited samples—using easy on-chip multiplexing, no upstream tagging required, for less than $600 per sample
Read about the performance advantages of Chromium assays over alternative methods in this independent Genentech study comparing single cell platforms >
Instrument-supported accuracy and reproducibility, featuring quick and easy processing

- Automate critical steps for a lower risk of manual error than with instrument-less methods and more reproducible results, with a demonstrated R2 value of 0.97 across runs, users, and timepoints
- Eliminate cumbersome pipetting steps and partition tens of thousands of cells in mere minutes, as part of a 1-day, hassle-free workflow with just 3–4 hours of hands-on time
- Easily increase the number of single cell projects as your research grows, and take advantage of seamless upgrades to access the full breadth of assays, including immune profiling and FFPE compatibility
Check out our instrument family page to explore options for more sample types, additional multiomic readouts, and applications >
Ensure your success with end-to-end support
- Access tailored training sessions, speak directly with 10x Genomics specialists, and download comprehensive resources, including User Guides, Protocols, How-to Videos, and more
- Be successful at every step from optimized sample prep to intuitive processing and visualization software as part of our integrated analysis workflows—no bioinformatics experience needed
End-to-end support means you have a trusted partner to help move your research forward, from sample prep to data analysis. And now, that last step is faster and easier than ever before with Automated Cell Annotation, available as part of our Cell Ranger analysis pipeline and through the 10x Genomics Cloud Analysis platform.
Watch the webinar to get all the details >
Discover all the ways we are making single cell more affordable
We're thrilled to be making single cell more accessible than ever before. Chromium Xo is just one of several advancements making it possible to drive down your costs across a wide range of applications:
Easy, accessible single cell multiplexing
Achieve cost-effective gene expression studies, even at small scales, with on-chip multiplexing—no extra steps. See how this easy workflow reduces per-sample costs.
Discover Universal Multiplex >
Flex Gene Expression, powered by GEM-X
Enable large-scale studies for fresh, frozen, and fixed samples (even FFPE!) with superior single cell performance at < $0.01 per cell. Check out GEM-X Flex Gene Expression on the Chromium X.
Meet GEM-X Flex >
Explore the full breadth of the Chromium advantage
Discover the Chromium innovations making single cell more affordable than ever, at any scale, without compromising on quality.
Save more with Chromium assays >
Ready to bring the Chromium advantage to your bench?
Speak with sales >
Footnote:
1Annotation is performed using a model that was co-developed by 10x Genomics and the Cellarium AI Lab at the Data Sciences Platform of the Broad Institute.