Why do only some patients respond to therapies? How to you best untangle complex tumor microenvironment, or how can you best translate your findings to inform better patient outcomes.
These questions are why we built Xenium In Situ. Explore the resources below and see how single cell spatial imaging with Xenium can reshape your immuno-oncology research—and what researchers like you have already accomplished with it.
Blog: The Value of Multiplexed RNA
High-plex single cell spatial RNA: Adding an entire new dimension to your imaging studies
- Comprehensive views of cell types and states with the simultaneous analysis of up to 5,000 genes
- Deeper characterization of how cells interact and communicate
- Richer datasets, not just RNA: also get histology (H&E) and immunofluorescence from the same tissue section
Read the blog
Fynn Biosciences preprint
Revealing potential spatial biomarkers for immunotherapy response
A new preprint showcases how spatially resolved biomarkers helped untangle complex biology in the tumor microenvironments of several breast cancer subtypes and revealed:
- Immune cell composition and distribution throughout the tumor
- Cellular neighborhoods and cellular proximity
- Cell-type-specific ligand–receptor communication between immune and cancer cells
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Xenium immuno-oncology application note
App Note: Molecular dissection of the tumor microenvironment using the Xenium Human Immuno-Oncology Panel
See how immuno-oncology-focused single cell spatial with Xenium In Situ:
- Precisely identifies cell types and their spatial localization throughout various tumors
- Obtains functional information about cell states, such as identifying exhausted T cells
- Unites histology and gene expression data to resolve clinically relevant features, such as tertiary lymphoid structures and pseudopalisades
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