Developing new therapeutics for brain disorders, translating findings into human patients, and creating better models of disease all require the ability to unravel the intricate complexities of the CNS.
Explore the resources below to see how the Visium and Xenium Spatial platforms can help you untangle the complex neurobiology of disease, and learn how other neuroscientists are leveraging these powerful tools for groundbreaking work.
Blog: Untangling the CNS with high-plex spatial RNA & multiplexed protein
Read the blog to see how the Visium and Xenium platforms can revolutionize our understanding of the brain with:
- Greater characterization of cell types, states, neighborhoods, and cell–cell interaction networks
- Simultaneous analysis of hundreds to thousands of RNAs and protein from a single section
- More comprehensive data from your precious samples, without sacrificing your current analytes
Read now >
Customer interview: How Alon Millet ID’d the “what” and “where” of a new Alzheimer’s-associated cell type
Amyloid is a hallmark pathology in Alzheimer’s disease, but how it affects cellular neighborhoods, cell–cell communication, and cellular function is still quite murky. See how Alon Millet (Rockefeller University) studied this by:
- Using Chromium multiomic single cell RNA- and ATAC-seq to identify a novel population of “exhausted” microglia in aged AD model mice
- Leveraging Xenium to validate the existence and spatial localization of these microglia in human Alzheimer’s disease patients
- Demonstrating the functional impairments in this novel microglial population, such as impaired amyloid clearance
Read now >
Application note: Exploring Alzheimer's-like pathology at subcellular resolution using Xenium In Situ
Download this application note to see how the Xenium platform let us dig deep into Alzheimer’s disease by:
- Analyzing hundreds of transcripts at subcellular resolution and visualizing cell-type composition in cellular neighborhoods surrounding amyloid plaques
- Permitting the simultaneous visualization of both spatial RNA and protein in a single tissue section for true multiomic insights
- Characterizing disease-associated glia and their relative proximities to amyloid plaques
Register for your copy >
Spatial brain datasets: See the Xenium and Visium HD platforms for yourself
In science, seeing is believing. Check out our robust collection of data from the Xenium and Visium platforms on brain and try them out for yourself.
Xenium platform:
- FFPE human brain tissue from healthy, glioblastoma, and Alzheimer's disease patients
- Data from the above application note, with fresh frozen mouse brain from an Alzheimer’s disease model and IF-stained amyloid plaques
- Fresh frozen mouse brain analyzed with the Xenium Prime 5K assay
Visium HD platform:
- Fresh frozen, fixed frozen, and FFPE mouse brain
Both:
- Fresh frozen mouse brain analyzed with a post-Xenium Visium assay
And more!
See them now >
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