Enhanced Pathology with Visium Spatial Solutions

Bridge Digital and Molecular Pathology


Transform disease insights with enhanced pathology. Resolve tumor heterogeneity with the ability to map disease-induced gene expression changes and localize cell subtypes in morphological context. Identify novel biomarkers with access to a comprehensive tissue-wide gene expression profile. With Visium Spatial solutions you can examine hundreds to thousands of gene expression profiles simultaneously in H&E and immunofluorescence-stained pathological sections, bridging digital and molecular pathology. 


Researcher Perspectives

Dr. John Carpten, USC cancer researcher, and technology inventor Dr. Joakim Lundberg of Sweden’s KTH Royal Institute of Technology share their excitement about Visium Spatial Gene Expression and how it could transform tissue analysis. Hear their stories.  

AMP 2020 Workshop

Watch the 10x Genomics workshop at AMP 2020 to hear from Dr. Joseph Powell, Associate Professor at the Garvan Institute of Medical Research, as he discusses the genetic and spatial heterogeneity of human papilloma virus–associated cancer of the oropharynx, revealed using Visium Spatial Gene Expression. Explore his research.  


Explore these resources to learn how spatial gene expression complements pathological annotation and single cell analysis to reveal a more complete picture of tumor complexity.

What new insights into tumor biology are now possible with enhanced pathological annotation? Find out how spatial gene expression, complemented with single cell analysis, is advancing our understanding of tumor heterogeneity, the influence of tissue architecture on cancer progression and immune infiltration, therapy-induced remodeling of immune, stromal, and tumor compartments, and more, in this brochure. Download →
Improving diagnoses and therapeutic outcomes for treatment-resistant tumors like triple negative breast cancer (TNBC) requires deep investigation of its underlying biology. Read this application note to learn how the combination of single nuclei RNA-seq data, pathologist annotation, and spatial gene expression provided improved resolution of intratumoral heterogeneity, localization and characterization of putative cancer stem cells, and cell subtype identification of infiltrating immune cells. Download →


Spatially resolved gene expression profiles in human glioblastoma
Spatially resolved molecular investigation of triple negative breast cancer




Review key publications for oncology and neurodegenerative diseases that demonstrate the depth of tissue analysis and disease insights that are possible with Visium Spatial solutions.

Spatial Gene Expression to Resolve Tumor Heterogeneity
  • S Nagasawa et al., Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast. medRxiv. (2020). [Read more]
  • AL Ji et al., Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma. Cell. 182 (2), 497–514.E22 (2020). [Read more]
  • E Berglund et al., Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity. Nat. Comm. 9, 2419 (2018) [Read more]
  • K Thrane et al., Spatially Resolved Transcriptomics Enables Dissection of Genetic Heterogeneity in Stage III Cutaneous Malignant Melanoma. Cancer Res. (2018). [Read more]
Spatial Gene Expression to Understand Neurodegenerative Disease Progression
  • Chen et al., Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. Cell. 182 (4), 976–991.E19 (2020). [Read more]
  • S Maniatis et al., Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis. Science. 364 (6435), 89–93 (2019). [Read more]

Explore Visium

Find a comprehensive suite of spatial analysis solutions to take your pathological annotation to the next level.

Learn more about how histological spatial information is coupled with whole transcriptome analysis to gain a new perspective on tissue biology.
10x_Thumbnail_AMP_Pathology_spatialProteomics_screenshot.png Learn how immunofluorescence builds onto the Visium Spatial Gene Expression platform, enabling multiomic tissue phenotyping with protein and mRNA visualization.

Explore Spatial Proteomics →
Experience the wealth of data provided by Visium with Gateway slides that let you analyze two tissue samples at an introductory cost.

Profile a defined set of transcripts in an entire tissue section with comprehensive, pre-designed human panels for cancer, immunology, neuroscience, and drug discovery, or define your own custom content.

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