- An overview of the Chromium Single Cell Immune Profiling Solution workflow and how it compares to traditional drug discovery approaches, such as hybridoma generation
- How LIBRA-seq was used to discover novel broadly neutralizing anti-HIV mAbs with therapeutic potential
- Leveraging LIBRA-seq and related technologies to isolate, characterize, and engineer native, paired, full-length, fully human antibodies for pharma programs
- Applying LIBRA-seq to re-engineer existing antibodies and augment existing antibody portfolios
- Performing epitope mapping with antigen mutants to study antibody binding to globally representative variants of proteins
Wyatt McDonnell, PhD
Dr. Wyatt McDonnell is a computational immunologist at 10x Genomics, where he focuses on single cell immunology and the adaptive immune system. As a former faculty member at Vanderbilt University, Wyatt studied the roles of B cells and T cells in human immune-mediated disease and helped co-develop the first high-throughput microfluidic single cell antibody discovery technology (LIBRA-seq).
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